Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 50mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Research Products International Corp ATP 100 G
An essential nucleotide triphosphate with a variety of roles in energy metabolism, signal transduction and nucleic acid metabolism.
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | 34369-07-8 | MFCD00150755 | 500G
Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | Purity: >=97% (HPLC) | 34369-07-8 | MFCD00150755 | 500G
Medchemexpress LLC Adenosine A1 receptor activator T62 | 40312-34-3 | 98.9% | 291.80 g/mol | C15H14ClNOS | 1 ML
Adenosine A1 receptor activator T62 is a selective positive allosteric modulator of the adenosine A1 receptor supplied for in vitro research. It is available as a solid or as a ready-to-use 10 mM solution in DMSO, with reported purity of 98.93% and a molecular weight of 291.80 g/mol. Follow the SDS for storage and safe handling.
- Allosteric enhancer of adenosine A1 receptor.
- Available as solid or 10 mM solution in DMSO.
- High reported purity suitable for biochemical and cellular assays.
- High solubility in DMSO (100 mg/mL) for easy formulation.
- Multilingual SDS provided for safety and handling guidance.